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These inconsistencies highlight the importance of a substrate-centered metabolic perspective

Seniors who are most medically motivated to start GLP-1 therapy those with severe obesity, established cardiovascular disease, or significant comorbidities are precisely the people who stand to gain the most from sustained treatment and who face the greatest health risk from abrupt discontinuation at the end of 2027

Disorders of Carnitine Biosynthesis Defects in carnitine biosynthesis can lead to a range of metabolic disorders, often with severe clinical implications