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NAD+ (nicotinamide adenine dinucleotide) isn't a peptide in the strictest sense, but it travels in the same longevity and wellness circles, so it's worth including

By concurrently modulating metabolic dysfunction and inflammatory signaling, GLP-1RAs could potentially reduce the required doses of biologics or other immunosuppressive therapies, thereby minimizing treatment-related toxicity while improving overall disease control

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In clinical trials, participants experienced progressive weight loss over many months, with results continuing to improve as treatment continued

Both are in late-stage clinical development and both add glucagon receptor (GCGR) activation on top of the GLP-1 backbone