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Currently approved options include orlistat, naltrexone/bupropion (Mysimba note that NHS commissioning of this medicine varies by local area), and semaglutide (Wegovy), which has a NICE technology appraisal recommendation for weight management

Injection site reactions are common, and the lack of standardised formulations means ingredient quality and sterility cannot be guaranteed outside regulated healthcare settings

De Simone R, Sansone M, Russo C, Miele A, Stornaiuolo A, Braca S

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What to Expect from MOTS-C Therapy: Clinical Evaluation: A clinician reviews a patients medical history, symptoms, metabolic markers, and laboratory results to determine whether investigational peptide therapy may be appropriate within a supervised care plan