12, 13, 14 Together, the pathological features of T2Dnotably elevated serum concentrations of inflammatory cytokines, glucose, insulin and free insulin-like growth factor-1 (IGF-1)provide a pro-tumorigenic environment that may account for the increased risk of diabetic and obese patients for the development of cancer at various sites 11 as well as the worse prognosis of patients with cancer that display one or more of these abnormalities
Metformin , a biguanide and first-line medication for type 2 diabetes, primarily reduces hepatic glucose production and improves peripheral insulin sensitivity
As GLP-1 therapy improves glucose control, this osmotic effect typically diminishes, potentially normalising previously excessive urination patterns
Safety of Semaglutide. Front Endocrinol (Lausanne)
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