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As demonstrated in Table 2, semaglutide was more cost-effective than all other GLP-1 RAs over a 30-year simulation period
8 Challenges in clinical application Considering the enumerated benefits of GLP-1RA compared to other glucose-lowering drugs including the reduction in HbA1c and weight reduction benefits alongside decreased risk for hypoglycaemia (122) it is not cost effective if used in combination with another incretin (107)
References Li N, Yang Q, Walker RG, Thompson TB, Du M, Rodgers BD
Total fat reduction over the full 12 weeks often ranges from 6 to 12 pounds for individuals maintaining reasonable nutrition, with some users reporting higher losses when combining the protocol with structured caloric deficits
