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Men and women are equally likely to inherent PCD, as its passed down in an AR (alternatively recessive) manner

For patients, this translates into higher cochlear drug concentration and longer action, with fewer systemic effects

PubMed PMID: 36707132

When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak