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Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line

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The evidence from published intervention trials is consistent: T/T individuals receiving adequate 5-MTHF + B12 + B6 supplementation normalize plasma homocysteine to levels similar to C/C individuals, restore BH4 availability and endothelial function, and reduce the functional consequences of MTHFR impairment across most of the five longevity mechanisms described above

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