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Another common reason is dehydration

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[3] The risk increases with higher doses, prolonged use, advanced age, and in patients with a history of peptic ulcer disease or gastrointestinal bleeding

Expert Opin Biol Ther 10:801806 Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RG, Greig NH, Egan JM (2000) Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats

The drug interaction potential of berberine hydrochloride when co-administered with simvastatin, fenofibrate, gemfibrozil, metformin, glimepiride, nateglinide, pioglitazone and sitagliptin in beagles