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The activation of necroptotic cell death pathways in the ovary contributes to the deterioration of ovarian function, further accelerating conditions like DOR (Figure 6B)

GLP-1 and GIP receptors influence appetite signalling and insulin response

The relation between TMAO and chronic disease can be ambiguous, involving kidney function [79], disturbed gut-blood barrier [83], or flavin-containing monooxygenase 3 genotype [84]

Improved glycemic control is associated with lower risk of complications related to metabolic syndrome

15 GLP-1RAs also improve -cell proliferation and inhibit -cell apoptosis to promote cellular survival by preventing oxidative stress and lipotoxicity