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semaglutide alone resulted in 34.5% of weight loss from lean mass, while the combination reduced this proportion Muscle Growth: In healthy participants, thigh muscle volume increased by 7.7% with trevogrumab 6 mg/kg plus garetosmab 10 mg/kg after a single dose, and fat mass decreased by up to 6.7% Side Effects The combination therapy, especially the triplet regimen, is associated with a higher incidence of side effects compared to semaglutide alone
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Furthermore, Zepbound directly addresses the biological challenges of weight management by offsetting the body's typical response to reduced calories, aiding sustainable long-term upkeep
Both are in Phase 2 clinical trials, and Pitts said the company will make a decision by the end of the year about which to move forward into late-stage testing
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