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MRS voxel sizes were: 30 (AP) x 30 (CC) x 30 (RL) mm 3 in SM1, 26 (AP) x 24 (CC) x 40 (RL) mm 3 in Thal, 30 (AP) x 20 (CC) x 40 (RL) mm 3 in mPFC, and 30 (AP) x 30 (CC) x 30 (RL) mm 3 in SMA, as shown in Figure 1

The result demonstrated a significant increase of intracellular ROS production in the chondrocytes exposed to 200 M H 2 O 2 , while metformin effectively reduced ROS levels (Fig

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