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Joint discomfort associated with B12 supplementation is uncommon and not listed amongst the recognised adverse effects in the Summary of Product Characteristics (SmPC) for licensed B12 preparations or in the British National Formulary (BNF)
Always follow dosage instructions and seek medical advice if you have pre-existing health conditions.
Adam O, et al
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
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