weight regain after stopping glp-1 medications Real-world studies of discontinuation showed that patients often at a significantly faster pace than other weight-loss methods. At the same time, however, novel strategies aimed at countering those GLP-1 weight-loss medications lead to

Having an exit strategy from day one, whether that involves keto or another approach, puts you in a fundamentally different position than someone who starts GLP-1 therapy without thinking about how it ends

Research in Diabetes found that just one week of mild sleep restriction decreased insulin sensitivity by 25% in healthy adults. That means the body has to work harder to clear glucose, keeps insulin elevated, and promotes fat storage regardless of how much less someone is eating

Those with severe kidney or liver disease, pregnancy or breastfeeding, or a history of lactic acidosis

NICE recommends PDE5 inhibitors (sildenafil, tadalafil) as first-line ED treatment, with success rates of 60-70% and well-characterised safety profiles

doi:10.1016/j.molmet.2019.09.010 2