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Oral meds at their currently available doses have typically ranged from 5%-7%, though newer studies with higher doses of oral semaglutide are showing results in the 10%-12% range over 68 weeks. So while injections still lead, oral GLP-1 medications are evolving quickly

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The FDA prescribing information does not contraindicate tirzepatide in patients who have undergone gallbladder removal, and the medication's effectiveness is not affected by gallbladder status

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The phase 2 dose-ranging trial (NCT02970942) included 320 individuals with histologically proven MASH and hepatic fibrosis F1-F3, randomizing them 3:3:3:1:1:1 to daily subcutaneous administration of semaglutide 0.1, 0.2, or 0.4 mg, or placebo for 72 weeks [18]