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Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]

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BMC Bioinformatics 19:547557

A landmark 2-year randomized, double-blind, placebo-controlled trial (Nass et al., Annals of Internal Medicine, 2008, N=65 healthy elderly adults aged 60-81) demonstrated that 25 mg/day MK-677 restored GH and IGF-1 secretory profiles to levels characteristic of healthy young adults