Dec2025;15(12):1055-1063
James McKoy, MD Rheumatologist (former) Kaiser Permanente Moanalua Medical Center Moanalua, Hawaii OnabotulinumtoxinA (Botox, Botox Cosmetic) Botox - Cervical dystonia, severe primary axillary hyperhidrosis, strabismus, blepharospasm, neurogenic detrusor overactivity, chronic migraine, upper limb spasticity Botox Cosmetic - Moderate to severe glabellar lines, moderate to severe lateral canthal lines, known as crows feet AbobotulinumtoxinA (Dysport) - Upper and lower limb spasticity, cervical dystonia, and moderate-to-severe glabellar lines in adults
Bacteriostatic water contains 0.9% benzyl alcohol, which inhibits bacterial growth and preserves the solution for up to 30 days
Triple-hormone-receptor agonist Retatrutide for obesity: Phase 2 trial (48-week study, up to 24% weight loss) American Diabetes Association (2023) ADA Press Release: Novel agent Retatrutide results in substantial weight reduction (83rd Scientific Sessions, Phase 2 data) ADA Meeting News (2023) Phase 2 trial results: benefits of Retatrutide in obesity, type 2 diabetes, NASH (83rd ADA Scientific Sessions coverage) ClinicalTrials.gov Study of Retatrutide (LY3437943) in adults with obesity (NCT04881760
But others could face more serious issues like: Prolonged bleeding from cuts or injuries Nosebleeds (epistaxis) Gingival bleeding Menorrhagia in women In severe cases, gastrointestinal or intracranial bleeding Spotting these symptoms early is key
