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miR-124 further modulates immune homeostasis by normalizing HG-induced microglial hyperactivity, suppressing inflammatory mediators (e.g., Tnf-, Ccl2, Ccl3), and downregulating transcription factors (PU.1) and lipid raft proteins (Flot1), thereby preventing vasoregression and neuroretinal dysfunction (48)

Gastrointestinal adverse events only led to discontinuation in the semaglutide group (2.2%)

Theres a good chance that, as we have more patients who get GLP-1 agonists for obesity, we might find similar results, Thosani says