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First, FAs synergize with monosodium urate (MSU) crystals to amplify macrophage activation through TLR2/MyD88/NF-B and TLR4-MD2/MyD88/NF-B signaling, leading to NLRP3 inflammasome assembly and IL-1 maturation (41)

The majority of animal studies have found that isothiocyanates inhibited the development of cancer when given prior to the chemical carcinogen (pre-initiation)

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