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These patients are often recommended to receive 1 mg of oral vitamin B12 daily indefinitely, but intramuscular injections may be necessary if oral supplementation is insufficient Mahawar2018Langan2017

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Cell-culture research has shown that reducing NNMT was associated with less lipid accumulation in fat cells, while increasing NNMT was associated with more suggesting NNMT contributes to adipocyte function rather than simply marking metabolic dysfunction