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Although the potential gene-environment interactions that have been identified are of small to moderate magnitude (probably limited by the number of populations included), 80,81 we should regard hereditary variants and environmental factors as additive risks in the prediction of breast cancer susceptibility

504 Increased number of GFAP-positive astrocytes, oligodendrocytes and microglia were detected in the striatum, with no changes in glial numbers in the amygdala

However, the cardiovascular outcomes trial (SURMOUNT-MMO) remains ongoing, so we cannot yet confirm whether these surrogate improvements translate to reduced events