What the weight regain data reveals about stopping treatment The STEP 1 extension study tracked participants after they discontinued semaglutide

Seek immediate medical attention (attend A&E or call 999) if blood in stool is accompanied by: Large volumes of bright red blood or continuous bleeding Dizziness, fainting, or signs of significant blood loss Severe abdominal pain or rigidity Vomiting blood or coffee-ground material Black, tarry stools with a foul odour (melaena), suggesting upper gastrointestinal bleeding Rapid heart rate, pallor, or confusion Contact your GP promptly (within 24-48 hours) if you notice: Small amounts of bright red blood on toilet paper or coating the stool Persistent change in bowel habits lasting more than three weeks Unexplained weight loss Persistent abdominal pain or bloating Blood mixed throughout the stool Recurrent episodes of rectal bleeding According to NICE guidance (NG12), patients aged 50 and over with unexplained rectal bleeding should be referred via a suspected cancer pathway (two-week wait) to exclude colorectal cancer

Common side effects nausea, vomiting, diarrhea, constipation and rarer complications such as pancreatitis remain the same as the brand-name version, Rodrigues told the same outlet
Higher protein intake enhances satiety, supports muscle preservation, and provides a thermic effect that partially compensates for the loss of GIP-mediated energy expenditure
Its essential for: Red blood cell formation Neurological function DNA synthesis Metabolism of fats and carbohydrates Energy production Since B12 is naturally found in animal products such as meat, dairy, and eggs, individuals following vegetarian or vegan diets are often more susceptible to deficiencies