glutathione s transferase mechanism Schematic representation of the structure of a Catalytic mechanisms of Cys-GSTs. The

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A parallel phenotype was observed in paraquat-treated fly model where Sp administration resulted in lower accumulation of oxygen radicals in mitochondria of brain neurons (Fig

Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40