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Menstrual irregularities are not currently listed among the primary side effects in prescribing information for semaglutide or tirzepatide

Daveluy A, Gniaux H, Thibaud L, Mallaret M, Miremont-Salam G, Haramburu F

5.2 Rare serious adverse events: individualized screening and monitoring Gallbladder disease: GLP-1RAs are associated with an increased risk of gallbladder-related events, often occurring in parallel with mechanisms such as rapid weight loss and cholestasis (143)

Pricing, medications, results, and which GLP-1 provider wins in 2026

Roughly half of subjects receiving the test drug met the primary outcome of at least a 10mm increase in Schirmer score at day 14, up to a fourfold increase over controls treated with the vehicle only, according to the press release