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doi: 10.1056/NEJMoa1901118 44 GersteinHCSattarNRosenstockJRamasundarahettigeCPratleyRLopesRDet al

Consequently, although GLP-1RAs hold considerable promise for RA treatment, their clinical translation is constrained by both unresolved mechanistic questions and systemic administration failing to achieve therapeutic intra-articular concentrations constrain their application

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This slow, stepwise approach is not the same as microdosing, which calls for maintaining the original, low dose