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With major players in this space actively pursuing legal and regulatory strategies to limit compounding of their blockbuster weight-loss and diabetes medications, and with Congress engaged in ongoing debate over the FDAs authority to restrict compounding when drug shortages resolve, this letter gives every stakeholder something concrete to point to

Variants in these genes may influence how efficiently semaglutide engages its target, contributing to differences in weight loss, metabolic improvement, and side-effect tolerance across individuals

Members with genetic predisposition to lower baseline GLP-1 pathway activity may particularly benefit from dietary GLP-1 activators like allulose when combined with targeted medication therapy

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Implications for the GLP-1 market: More employers will get ahead of the high costs associated with rising GLP-1 use by significantly restricting or eliminating coverage for the drugs, particularly as new oral formulations broaden their appeal