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The trial documented nausea, vomiting, diarrhea, and constipation as the most common adverse events, with incidence peaking during dose escalation and declining at stable doses

We restricted the study cohorts to patients with a diagnosis of type 2 diabetes and without use of any of the two drug classes being compared for the past 365 days, aged 18 years (65 years for Medicare), and with at least 12 months of continuous insurance enrollment before cohort entry