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The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]
The primary centers in the brain involved in the control of appetite are the hypothalamic-pituitary axis and the brain stem
however, in an acid wash assay (Supplementary Figure 2G), TR-FRET signals of each FITC-ligand bound to internalised GLP-1R labelled with SNAP-Lumi4-Tb suggested that endosomal binding of each compound is similar (Figure 3H)
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