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BMC Med 14, 103 (2016).

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higher doses may be used in some circumstances in line with BSH guidance, as passive absorption can partially compensate for absent intrinsic factor at high doses

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The NIH Office of Dietary Supplements, citing Institute of Medicine recommendations, advises that it is advisable for those older than 50 years to meet their RDA mainly by consuming foods fortified with vitamin B12 or a supplement containing vitamin B12. This recommendation reflects the fact that 10 to 30% of older adults lose the ability to efficiently absorb naturally occurring B12 from food

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