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A physician consultation confirms whether you qualify before your first dose
Extending the time at a dose before stepping up is a standard, evidence-informed way to improve tolerability
These pain-relieving effects are blocked by drugs that affect norepinephrine, but not serotonin, suggesting that the pain relief works through adrenergic pathways (9)
Rapid weight loss, changes in meal timing, and shifts in serotonin and norepinephrine activity may all contribute to initial sleep disruption during the first 4-8 weeks of therapy
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