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This is speculative, but it is how health economists will likely evaluate the drug once real-world pricing data becomes available

Later in 2022, the FDA granted tirzepetide fast track designation for overweight and obesity in adults.6 To date, tirzepetide hasnt been FDA approved for weight loss (see table Current FDA-Approved Mono and Dual Agonists for details about weight management medications)

This sublingual route of administration bypasses the digestive system, avoiding the first-pass metabolism in the liver, which can significantly reduce the bioavailability of certain medications when taken orally