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Randomized controlled trial of an integrated approach to treating insomnia and improving the use of positive airway pressure therapy in veterans with comorbid insomnia disorder and obstructive sleep apnea

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1012 Artificial intelligence meets clinical trial design: A test case in predicting patient achievement of minimal significant difference using conditional generative adversarial networks Siddharth Kakked 1 1 OPEN Health, Falmouth, Maine, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :1012 Aims This study investigates whether a conditional Generative Adversarial Network (cGAN) can reliably predict the probability of successfully achieving a clinical trial endpoint