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doi: 10.1016/j.gene.2019.06.001 32 LebreMCVergunstCEChoiIYAarrassSOliveiraASWyantTet al

Across multiple phase III trials, tirzepatide has consistently produced greater reductions in glycated hemoglobin and body weight compared with established GLP 1 receptor agonists and other standard therapies

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A dose-response analysis across 39 randomised trials and 33,354 participants found that nausea risk rose fastest across the lowest doses, then showed a tendency to plateauing at highest dosages