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Several studies have demonstrated that the GLP-1 receptor agonists such as extendin-4 and liraglutide can activate AMPK signalling in multiple tissues and cell types, including cardiomyocyte hyperglycaemic [20] or cardiac hypertrophy models [21], in rat INS-1 pancreatic beta cells [22], and in L6 myotubes, resulting in the sensitisation of insulin-stimulated glucose uptake [23]