semaglutide can't sleep and Insomnia: What the Evidence Shows semaglutide insomnia Are you on

Retatrutide adds glucagon receptor (GCGR) agonism to the GIP and GLP-1 receptor activity present in dual agonists

Common side effects include: Feeling sick (nausea) Vomiting Diarrhoea Constipation Indigestion or bloating These problems usually improve over time as your body becomes accustomed to the medicine

While semaglutide targets the GLP-1 receptor, tirzepatide acts as a dual agonist (GLP-1 and GIP), which may influence the profile of adverse events

Semaglutide and tirzepatide commonly cause gastrointestinal side effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort

More importantly, studies show that the majority of patients maintain significant weight loss for decades, making it one of the most effective long-term solutions for obesity management