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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
Users and researchers have documented effects across several domains of health and performance, though it bears mentioning that much of this evidence comes from animal studies, small human trials, or anecdotal reports rather than large-scale clinical trials
Zhang S et al
They will check your B12 levels and how youre doing
Class Small-molecule NNMT inhibitor
