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Obstruction of the sigmoid colon by mass or cancer can lead to difficulty having bowel movements despite laxatives, and if severe enough, can also result in abdominal pain, nausea, and vomiting. Prevention Get regular, vigorous exercise

Retinoids and peptides are also beneficial in stimulating collagen production

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GLP-1 medications are FDA-approved for chronic weight management in adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition

Gastroenterology Advisor Skelley JW, et al