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The primary explanation for this drug interaction seems to be a reduction in enterohepatic circulation of valproic acid
*Correspondence: Hui Chen [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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A common starting strategy for patients with sensitive systems is to begin with 250 mg to 500 mg in the morning, gradually increasing the dose and adding a second midday administration as tolerated
