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Example of toxic acetylated metabolite Liver damage Highly reactive specie Mechanism of acetylation Acetyl CoA is the activated carrier for acetyl group The reaction catalyzed by the soluble acetyltransferase enzyme: Mainly found in liver Might found in lung, spleen, GIT and red blood cells Acetylation The rate of acetylation is mainly affected by the existence of genetic polymorphism

10.1016/j.ebiom.2018.12.062 105 WangL

How Much Vitamin B12 Is too Much

On rare occasions some patients do find that B12 improves their sleep if you fall into this category then using B12 at night may be better for you

B12 injections can reverse debilitating symptoms, alleviating the fatigue and weakness associated with anemia