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DeFoor and Dekker ( Arthroscopy , 2024) noted the scarce orthopaedic literature investigating the clinical use and outcomes of such therapeutic peptides while acknowledging that the market continues to expand rapidly

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The theoretical basis of this study is as follows: OKGM and EW were cross-linked (based on the Schiff base) to form a self-repairing EK hydrogel, and the amino group of active peptide GHK-Cu can also form Schiff base bond with the aldehyde group of OKGM

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The goal is to create an internal environment that is primed for regeneration on multiple fronts