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Measured genes were glutamate-cysteine ligase, catalytic subunit ( GC ), glutathione synthase ( GS ), glutathione reductase ( GR ), glutathione S-transferase ( GT ), and phospholipid-hydroperoxide glutathione peroxidase ( GPx )
Wong and Billiar, 1995
Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site
Because IV glutathione peaks rapidly (within 30 to 60 minutes IV) and clears within hours, there is no need to pause NMN or NR on infusion days
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