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Maintaining this feedback system is important in research focused on long-term endocrine stability

The classical somatomedin hypothesis (Salmon and Daughaday, 1957, foundational sulfation factor research) assumed all peripheral IGF-1 came from this hepatic source

In this review, we have discussed the potential mechanisms of renal tubular injury in DKD, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death

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