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Other activities, such as the use of firearms or attendance at loud sporting events or concerts, can lead to hearing loss

Whether twice-daily dosing produced better outcomes cannot be determined from self-reported data alone

As reviewed elsewhere [79, 86], impairments in redox homeostasis and susceptibility of increased oxidative stress are linked to glutamatergic dysfunction due to (1) hypoactive NMDA receptors, (2) to degeneration of fast-spiking parvalbumin-positive GABAergic interneurons that are essential for fast local neuronal synchronization, (3) to dysfunctional oligodendrocytes resulting in poor myelination and thus impairing axonal integrity and signal conduction across brain areas, and (4) to neuroinflammation

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He says its the natural order of scientific discovery that comes from a deeper understanding of these medications obtained through years of research and study.