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Horm Res 2000

Because roughly 70% of daily GH secretion occurs during slow-wave sleep, this improvement creates a positive feedback loop: deeper sleep triggers more GH release, and higher GH levels promote more restorative sleep patterns

Mechanistic work probing the receptor-selectivity contribution of the Aib and D-2-Nal residues, where targeted residue substitution can be examined for its effect on the cortisol- and prolactin-sparing profile that distinguishes Ipamorelin from GHRP-2 and GHRP-6