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doi:10.1155/2012/324832 Hussain M, et al

CB-839 is the most advanced GLS1 inhibitor currently in clinical practice and has been shown to effectively inhibit tumor proliferation ( L-asparaginase can deplete plasma Gln and is widely utilized as an adjuvant therapy in lymphoma ( In vitro experiments on lung cancer cells revealed that L-asparaginase treatment significantly induced autophagy activation in A549 cells, leading to their apoptosis ( 5 Discussion Metabolic reprogramming is essential for the advancement of tumors and has become a central topic in cancer research lately ( While substantial progress has been accomplished in the study of tumor Gln metabolism in recent years, several key issues remain to be addressed (1)

Furthermore, the pro-inflammatory cytokine levels of IL-6, IL-12p70, IL-1, and total nitrite concentration are reduced in the brains of mice treated with liraglutide (142)

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