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Key genes include GLP1R (the GLP-1 receptor), GIPR (the GIP receptor targeted by dual agonists), TCF7L2 (strongly linked to type 2 diabetes and incretin-driven insulin secretion), and FTO (appetite and body weight)
On its own, modest, often a few percent of body weight
However, it is not universally safe for everyone , and it should never be given without prior evaluation
After discontinuing semaglutide but continuing metformin for two years, they regained only one-third of their lost weight , with 21 out of 25 women maintaining a lower weight than their starting baseline
FDA approved #Wegovy as a daily pill: Oral #semaglutide 25 mg
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