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or extended-release metformin with evening meals at doses of 1000 or 2000 mg for 12 weeks
Common gastrointestinal effects include nausea, vomiting, and constipation, typically emerging during dose escalation
Limited human pharmacokinetic evidence supports absorption and conversion, but it does not establish that S-acetyl glutathione is clinically superior to every reduced or liposomal product
"Way back, when there really weren't too many other agents for obesity treatment," she'd prescribe more of it, she told Insider, but that was largely because "there wasn't anything else." But metformin's effects on weight loss are "kind of mild," compared to newer drugs like semaglutide, Apovian said, and persistent side effects like stomach cramps and diarrhea are a common concern among patients taking metformin
Brocco et al., 2020
