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Clinical trials show GLP-1 receptor agonists reduce waist circumference by approximately 13.5 cm with semaglutide after 68 weeks, with imaging studies demonstrating significant decreases in visceral adipose tissue volume

If you have medical reasons for significant weight loss, it is best to talk to your healthcare provider about FDA-approved options

GIP receptor activation appears to enhance the body's insulin response and, according to emerging evidence, also acts directly on fat tissue and the brain to reinforce the caloric deficit

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GLP-1 receptor agonists for weight management must be prescribed through Tier 3 services