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Oral formulations continue to be developed, which may reduce some barriers to use

In addition, GLP-1 RAs have been identified as an important drug class for not only glucose-lowering but also in reducing cardiovascular disease (CVD) events in adults with T2DM and high atherosclerotic cardiovascular disease (ASCVD) risk.1 GLP-1 RAs stimulate glucose-dependent insulin release in the gut after food intake and inhibit glucagon release with concomitant decreased gastric emptying and low risk of hypoglycemia

Outlook The GLP-1 agonists are an impressive new option for weight loss, especially in the setting of type 2 diabetes due to their glucose-lowering benefits

Any unexpected symptom that develops after initiating the combined protocol should be evaluated in the context of potential compound interactions

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