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[1] Although water-soluble vitamins are generally excreted through urine when consumed in excess, vitamin B12 is unique in that significant amounts are stored in the liver
We will analyse the effect of vitamin B 12 separately in the following subgroups: Vitamin B 12 status: based on cobalamin (cut-off: 150 pmol/L) based on low total homocysteine (cut-off: 10 mol/L) based on low methylmalonic acid (cut-off: 0.26 mol/L) Maternal body mass index (cut-off: 18.5) Vegetarian (yes/no) Birth weight (cut-off: 2500 g) In these subgroup analyses, the differences in the effect between the levels of the subgroups will be measured by including two-way interaction terms in multiple regression models
