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these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1

Metabolic reprogramming, a hallmark of cancer, is the reprogramming of specific metabolic pathways inside and outside the cell to meet the demands of rapid proliferation by affecting gene expression, cellular state, and the tumor microenvironment (26)

10.1007/s00018-021-04004-4 63 HakiminiaB.AlikiaiiB.KhorvashF.MousaviS

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